Description
UNIVERSITY OF NOTTINGHAM
Research Associate/Fellow in Quantitative and Spatial Metabolomics for Antimicrobial Resistance (Fixed-term)
Location: University Park
Salary: £31,387 to £46,485 per annum, depending on skills and experience (minimum £35608 with relevant PhD).
Reference: SCI006526
A position is advertised for a self-motivated and ambitious Research Associate/Fellow to contribute to a major £5M BBSRC Strategic Longer and Larger (sLoLa) Grant investigating the fundamental rules governing impermeability in Gram-negative bacteria. This large-scale, multidisciplinary programme brings together investigators at the University of Nottingham, University of Birmingham, Imperial College London and the Quadram Institute to address antimicrobial resistance through the integration of bacterial membrane biology, efflux systems, antimicrobial accumulation, quantitative mass spectrometry, spatial metabolomics and mathematical modelling. The post is based within the Centre for Analytical Bioscience (CAB) in the School of Pharmacy at the University of Nottingham. CAB houses extensive specialist mass spectrometry instrumentation, including high-resolution Orbitrap platforms (QExactive, Fusion Lumos), triple quadrupole LC-MS/MS systems, and surface and imaging MS technologies (e.g. AP-MALDI-MS and OrbiSIMS), providing a high-quality research environment for metabolomics, lipidomics, fluxomics and spatial molecular analysis.
The Research Associate/Fellow will play a central role in delivering the mass spectrometry and metabolomics components of this nationally significant programme. The role will involve the design and implementation of advanced quantitative and spatial metabolomics workflows to characterise antimicrobial uptake, intracellular accumulation and metabolic responses in Gram-negative bacteria. The successful candidate will work closely with programme investigators across partner institutions to ensure alignment of experimental design, data generation and interpretation across work packages.
In addition to contributing to consortium-wide objectives, the role holder will have opportunities to develop independent research directions aligned with the programme, publish high-impact outputs, and build national and international collaborations. The post offers an excellent environment for career development within a major UKRI- funded research initiative addressing one of the most urgent global health challenges.
The successful candidate will hold a PhD (or near completion) in metabolomics, analytical chemistry, mass spectrometry or a closely related discipline. They must demonstrate excellence in research and independent working, with strong expertise in advanced mass spectrometry including high-resolution MS and quantitative LC-MS/MS. Experience in targeted and untargeted metabolomics workflows, advanced data analysis (including multivariate statistics), and multidisciplinary collaboration is essential. Experience in spatial metabolomics or imaging mass spectrometry and familiarity with microbiological systems would be advantageous.
This full-time post (36.25 hours per week) will be offered on a fixed-term contract for 36 months with the possibility of an extension of 24 months dependant on funding.
Informal enquiries can be addressed to Dr Dong-Hyun Kim (dong- hyun.kim@nottingham.ac.uk). Please note that applications sent directly to this email address will not be accepted.
We pride ourselves on the collegial and supportive culture created by our staff. We are dedicated to creating an environment which enables both our staff to thrive and achieve their potential. Our commitment to Equality and Diversity has been recognised in the awarding of an Athena SWAN Silver Award.
Closing Date: Wednesday 13 May 2026
